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. 2023 Mar 10;62(4):53. doi: 10.3892/ijo.2023.5501

Figure 2.

Figure 2

Established CARs have specific reactions to target antigens. (A) Characteristic FC (left) and histograms (right) of CD69 expression levels of different CAR-T cells following 12 h of provoking by target antigens (recombinant human GPC3 and PD-1 proteins). (B and C) Concentrations of IL-2 and IFN-γ released by the different CAR-T cells secreted upon encountering target antigens for 24 h, as examined by ELISA. Data are presented as the mean ± SD. *P<0.05, **P<0.01 and ***P<0.001. ns, not significant; CAR, chimeric antigen receptor; FC, flow cytometry; GPC3, glypican-3; PD-1, programmed death 1.