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. 2023 Mar 2;14:1083339. doi: 10.3389/fimmu.2023.1083339

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Copyright © 2023 Frydman, Ellett, Jorgensen, Marand, Zukerberg, Selig, Tessier, Wong, Olaleye, Vanderburg, Fox, Tompkins and Irimia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Megakaryocyte immune behaviors observed and their possible sequelae in physiological systems. Megakaryocytes (MKS) were observed to chemotax and release extracellular chromatin webs in response to pathogenic stimuli and interact directly with pathogens. These behaviors, in combination with their presence in increased amounts in the blood and peripheral organs during severe inflammatory conditions, such as sepsis, may contribute to the response to pathogenic stimulus, including the contribution to the development of intravascular thrombosis in peripheral organs, such as the lungs and the kidneys.