Table 2.
Significant correlations between CSF core biomarkers and studied lipoproteins and metabolites controlled for age and gender in Apo-E groups.
| Variable | Apo-E status | |||||
|---|---|---|---|---|---|---|
| Negative | Positive | |||||
| Aβ-42 | TAU | P-TAU | Aβ-42 | TAU | P-TAU | |
| Lipoproteins | ||||||
| XXL VLDL | ||||||
| Rho | 0.186 | -0.003 | -0.033 | -0.022 | -0.210 | -0.208 |
| p value | 0.196 | 0.986 | 0.821 | 0.819 | 0.031 | 0.033 |
| L HDL | ||||||
| Rho | -0.175 | 0.201 | 0.241 | -0.027 | 0.081 | 0.049 |
| p value | 0.225 | 0.161 | 0.091 | 0.780 | 0.407 | 0.619 |
| M HDL | ||||||
| Rho | -0.132 | 0.386 | 0.400 | -0.082 | 0.122 | 0.115 |
| p value | 0.360 | 0.006 | 0.004 | 0.405 | 0.213 | 0.242 |
| S HDL | ||||||
| Rho | -0.060 | 0.385 | 0.355 | -0.072 | 0.068 | 0.089 |
| p value | 0.680 | 0.011 | 0.011 | 0.461 | 0.489 | 0.367 |
| Apolipoproteins | ||||||
| Apo-A1 | ||||||
| Rho | -0.158 | .225 | 0.263 | 0.003 | -0.006 | -0.036 |
| p value | 0.195 | 0.063 | 0.029 | 0.970 | 0.942 | 0.662 |
| Fatty acids | ||||||
| DHA | ||||||
| Rho | -0.136 | 0.095 | 0.154 | -0.157 | -0.075 | -0.110 |
| p value | 0.266 | 0.437 | 0.206 | 0.058 | 0.369 | 0.184 |
| LA | ||||||
| Rho | -0.200 | 0.032 | 0.090 | -0.021 | -0.043 | -0.065 |
| p value | 0.099 | 0.794 | 0.460 | 0.804 | 0.605 | 0.437 |
| Omega-3 | ||||||
| Rho | -0.119 | 0.094 | 0.146 | -0.155 | -0.133 | -0.164 |
| p value | 0.332 | 0.445 | 0.232 | 0.062 | 0.108 | 0.048 |
| Omega-6 | ||||||
| Rho | -0.212 | 0.083 | 0.145 | -0.047 | -0.039 | -0.062 |
| p value | 0.080 | 0.496 | 0.235 | 0.573 | 0.643 | 0.453 |
| PUFA | ||||||
| Rho | -0.204 | 0.088 | 0.151 | -0.067 | -0.056 | -0.082 |
| p value | 0.092 | 0.470 | 0.216 | 0.421 | 0.501 | 0.323 |
| MUFA | ||||||
| Rho | -0.083 | 0.068 | 0.093 | -0.136 | 0.010 | 0.007 |
| p value | 0.500 | 0.579 | 0.449 | 0.099 | 0.903 | 0.932 |
| Glycolysis-related metabolites | ||||||
| Glycerol | ||||||
| Rho | 0.262 | -0.013 | -0.048 | -0.012 | -0.058 | -0.046 |
| p value | 0.037 | 0.918 | 0.706 | 0.891 | 0.488 | 0.582 |
| Amino acids | ||||||
| Alanine | ||||||
| Rho | 0.237 | -0.116 | -0.159 | -0.023 | 0.043 | 0.032 |
| p value | 0.060 | 0.360 | 0.209 | 0.781 | 0.609 | 0.703 |
| Leucine | ||||||
| Rho | 0.305 | -0.132 | -0.181 | 0.017 | -0.049 | -0.024 |
| p value | 0.014 | 0.297 | 0.153 | 0.841 | 0.560 | 0.776 |
| Valine | ||||||
| Rho | 0.241 | -0.160 | -0.210 | 0.056 | -0.035 | -0.013 |
| p value | 0.056 | 0.207 | 0.096 | 0.509 | 0.677 | 0.877 |
| Phenylalanine | ||||||
| Rho | 0.231 | -0.030 | -0.026 | -0.096 | -0.046 | -0.054 |
| p value | 0.066 | 0.811 | 0.835 | 0.254 | 0.587 | 0.525 |
| Fluid balance metabolites | ||||||
| Albumin | ||||||
| Rho | -0.001 | 0.102 | 0.131 | -0.077 | -0.159 | -0.155 |
| p value | 0.997 | 0.422 | 0.303 | 0.362 | 0.058 | 0.065 |
XXL VLDL: extremely large very low-density lipoprotein, L HDL: large high-density lipoprotein, M HDL: medium high-density lipoprotein, S HDL: small high-density lipoprotein, DHA: docosahexaenoic acid, LA: linoleic acid, PUFA: polyunsaturated fatty acids, MUFA: monounsaturated fatty acids.