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. 2023 Mar 7;9(3):e14265. doi: 10.1016/j.heliyon.2023.e14265

Fig. 3.

Fig. 3

Effects of miR-1281 on the expression levels of wild-type and mutant ADCY1/DVL1-transfected cells. (A–B) ADCY1 and DVL1 mutation sites. (C–D) The miR-1281 overexpression plasmid was cotransfected with the ADCY1 or DVL1 wild-type/mutant reporter plasmid into HEK293 human embryonic kidney cells. A dual-luciferase reporter assay was used to detect the levels of the ADCY1 or DVL1 reporter after transfection. Compared with the miR-1281-NC-ADCY1/DVL1 wild-type group and miR-1281-mimics-ADCY1/DVL1 wild-type group, ####P < 0.0001, Compared with the miR-1281-mimics-ADCY1/DVL1 mutant type group and miR-1281-mimics-ADCY1/DVL1 wild-type group, ***P < 0.001, ****P < 0.0001.