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. 2023 Mar 9;31:101633. doi: 10.1016/j.tranon.2023.101633

Table 1.

miRNAs targeting PTEN (Ensemble: ENST00000371953) from miRWalk3.0.

miR Mechanism of action Cell Type
Described		 Inside EVs Hippo Signaling Ref.
miR-10a/b Activates pro-metastatic genes, promoting tumor cell invasion and metastasis. Migration. Ovarian cancer, bladder cancer, breast cancer, esophageal cancer, and gastric cancer cells. ECs. Image, table 1 + [164,165,166,167,168,169,170,171]
miR-17-5p*/3p Survival, proliferation, migration, regeneration.
EC morphogenesis and angiogenesis. Target TIMP1 Tsp1, PTEN.		 ECs, tumor cells Image, table 1 + ([78,88,89,172]
miR-19a/b-1*/-2⁎⁎ Help to suppress the sensitivity to anticancer drugs, and anti-apoptotic.
EC morphogenesis and tumor angiogenesis. Regeneration
Target TIMP1 Tsp1, PTEN.		 Gastric cancer cell line, ECs, leukemia cells (K562). Image, table 1 + [78,88,89,140,143,172,173]
miR-20a*/b-5p/3p⁎⁎ EC morphogenesis and tumor angiogenesis. Regeneration
Target TIMP1 Tsp1, PTEN.		 Breast cancer, myeloma cells, ECs. Image, table 1 ? ([139,140]
miR-21 Proliferation, EMT, angiogenesis. Repair spinal cord microvasculature. Maintaining of vSMC phenotype. In vitro in vivo models (several tumors, vascular repair, healthy). Image, table 1 + [83,86,97,134]
miR-23a/b-3p Proliferation, tumor progression, metastasis. Prostate cancer. [90]
miR-25-3p*** Up-regulation of miR-25 was correlated migration and invasion. Esophageal squamous cell carcinoma. [174]
miR-26a-1-5p/3p c-Myc increases miR-26a expression. miR-26a activates Akt signaling through direct PTEN targeting and increases VEGF, MMP2 expression. Increases proliferation and invasiveness. High-grade glioma, glioblastoma multiforme, lung cancer cells Image, table 1 + [90,91,175,176]
miR-26b Enhance growth, survival, and tube formation through PTEN targeting.
Inhibit the proliferation, migration, and EMT in epithelial cells through prostanoid pathway inhibition.		 EC, epithelial cells Image, table 1 [177,178,179]
miR-29a-5p Pro-angiogenic
YAP induces miR-29 to inhibit PTEN translation which activates PI3K–mTOR signaling to regulate proliferation and cell size.		 Lung cancer cells, ECs, epithelial cells, mice. Image, table 1 +
 ([138],[180]
miR-92a-1-5p*/a-2⁎⁎
miR-92b-3p 		EC morphogenesis and tumor angiogenesis. Regeneration
Target TIMP1 Tsp1, PTEN.		 ECs, leukemia cells (K562). Image, table 1 +
 [78,89,90,181,182,183]
miR-93-5p⁎⁎⁎ High proliferation, anti-apoptotic, and influence tumor size. Cisplatin resistance, suppressing PTEN and over activating AKT pathway. Angiogenesis Osteosarcoma cells, ovarian cancer, ECs, mouse hearts +
([135,184,185]
miR-103a-3p Downregulation of angiogenesis inhibitors expression, like TIMP3. Promotes cell transformation, and disrupt the endothelium integrity, increasing the vascular permeability. Endometrial and hepatocarcinoma cells, ECs. Image, table 1 + [127,128,129,130,131,186]
miR-105-5p Vascular permeability disruption. Downregulates ZO-1 expression, altering the vascular junctions. In vitro, ex vivo and in vivo assay in rodents. Image, table 1 [133]
miR-106a-5p/3p⁎⁎/ miR-106b-5p/3p⁎⁎⁎
miR-130a/b Proliferation, migration, and anti-apoptotic Glioma cell lines, squamous cell carcinoma. [187,188]
miR-181b/c-5p
miR-193/a-3p Cell proliferation, migration, 5-FU chemoresistance, and in vivo tumorigenicity through PTEN targeting.
Contradictory, functions like tumor suppressor miRNA, inhibiting migration, invasion, and EMT in vitro and metastasis in vivo in lung cancer.		 Gastric cancer cell lines ([189,190]
miR-200c-5p/3p Alters wound-healing capacity and colony formation. MT1-MMP (Membrane type-1 matrix metalloproteinase) and PTEN expression are regulated. Pancreatic cancer cell.
miR-205-5p Directly targets SMAD4, CYR61, CTFG, PTEN. Promotes proliferation, anti-apoptotic, migration, chemoresistance, and tumorigenesis in vivo. Regulated Erb/HER, PTEN/AKT axis.
Biomarker for cervical cancer patients.		 Ovarian cancers (OC) with poor diagnostic, cervical cancer cells, breast, lung, and NSCLC cancers. Image, table 1
[93,94,95,191,192,193,194]
miR-221-3p Downregulates PTEN and activates PI3K/Akt signaling. Induce cell survival, proliferation, carmustine, and cisplatin resistance. Osteosarcoma cells, Epithelial ovarian cancer (EOC) cells [195],[196]
miR-223 Downregulates PTEN and activates PI3K/Akt signaling. Ovarian cancer cells Image, table 1 [124]
miR-301a/b M2 macrophage polarization through PTEN targeting. Promote migration, invasion, EMT, and facilitate the lung metastasis of pericytes. Pancreatic cancer cells Image, table 1 + [126]
miR-382-5p Target PTEN and consequent activation of AKT/mTOR signaling. Increases proliferation, migration, and apoptosis avoidance. Increases vascular EC proliferation, migration, and tube formation. Hemangioma-derived endothelial cell, hypoxia in human gastric cancer cells [92,197]
miR-425 MALAT1 interacts with miR-425 preventing PTEN silencing. Induce apoptosis Plasma and plasma exosomes Image, table 1 [141]
miR-494-5p/3p Target PTEN and subsequent activation of AKT/eNOS pathway. Enhances proliferation, migration, invasion, and promotes angiogenesis. Hypoxic lung cancer cells, glioblastoma cells, ECs. [198,199]
miR-638 Dual PTEN and p53-targeting. Cell migration, invasion, proliferation, and anchorage-independent growth. Exogenous expression model in prostate cancer cells [163]
miR-939 ? ([132]
⁎

miR-17/92 cluster: located in chromosome 13, encodes miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a-1, lso known as oncomiR-1.

⁎⁎

miR-106a/363 cluster: located on chromosome X, encodes miR-106a, miR-18b, miR-19b-2, miR-20b, miR-92a-2, and miR-363.

⁎⁎⁎

miR-106b/25 cluster: located in chromosome 7, encodes miR-106b, miR-93, and miR-25.