Table 3.

Maternal and Neonatal Outcomes

	Progesterone Group (n = 121)	No Treatment Group (n = 253)	p-value
Maternal
GA at Birth (weeks, mean ± SD, median [range], [IQR])	38.1 ± 2.3	37.8 ± 2.7	0.319
	38.4 [27.7–42.7]	38.4 [26.2–42.8]
	[37.6–39.4]	[36.6–39.6]
Diagnosis to Delivery Interval (weeks, mean ± SD, median [range], [IQR])	8.2 ± 2.9	6.6 ± 3.2	< 0.001
	8.2 [0.8–16.2]	6.6 [0.1–16.8]
	[6.2–9.8]	[4.8–8.8]
Tocolytic Therapy for Threatened Preterm Birth (n (%))	82 (67.8)	164 (64.8)	0.574
Antepartum Corticosteroid Administration (n (%))	116 (95.9)	208 (82.5)	< 0.001
Mode of Delivery (n (%))			0.572
- Spontaneous vaginal	87 (71.9)	185 (73.1)
- Operative vaginal	10 (8.3)	27 (10.7)
- Caesarean	24 (19.8)	41 (16.2)
Neonatal
Apgar Score <7 at 5 min (n (%))	4 (3.3)	0 (0)	0.017
Birth Weight (grams, mean ± SD, median, [range], [IQR])	2878 ± 510	2907 ± 579	0.620
	2945 [1120–4145]	2930 [1020–4480]
	[2610–3180]	[2594–3312]
Fetal Sex (n (%))			0.439
- Female	57 (47.01)	130 (51.4)
- Male	64 (52.9)	123 (48.6)
NICU Admissions (n (%))	10 (8.3)	41 (16.2)	0.036
Days of Hospitalization (days, mean ± SD, median [range], [IQR])	5.7 ± 6.9	7.7 ± 13.5	0.060
	4.0 [1–44]	4 [1–160]
	[3–5]	[3–6]
Adverse Prematurity Outcome (n (%))
- Respiratory distress syndrome (RDS)	3 (2.5)	8 (3.2)	0.713
- Intraventricular hemorrhage (IVH)	2 (1.6)	1 (0.4)	0.551
- Necrotizing enterocolitis (NEC)	0 (0)	1 (0.4)	0.782
- Retinopathy of prematurity (ROP)	1 (0.8)	2 (0.8)	0.551
- Broncho-Pulmonary Dysplasia (BPD)	0 (0)	0 (0)	0.751
Any adverse prematurity outcome* (n (%))	4 (3.3)	9 (3.6)	0.490

^*Any adverse prematurity outcome is defined as one or more of the following complications: RDS, IVH, NEC, ROP, or BPD.