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. 2023 Mar 3;14:1121390. doi: 10.3389/fendo.2023.1121390

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Copyright © 2023 Siqueira, Batabyal, Freishtat and Cechinel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of miR-342-5p in breast cancer patients and its effect after exercise. Exercise was shown to increase the levels of exosomal miR-342-5p in humans submitted to 1-year rowing and rats that swam twice daily for 4 weeks. Authors reported an inhibitory effect of miR-342-5p on HER2 signaling which was associated with better overall survival and increased time to recurrence in breast cancer patients. It is relevant to point out that women diagnosed with early-stage breast cancer with estrogen receptor, progesterone receptor, or HER2 negative tumors showed reduced benefit on mortality and risk of recurrence of post-diagnosis exercise. Given that, it is possible to infer that patients with HER2-positive tumors will have higher susceptibility to physical activity/exercise benefits, although this was not tested.