Table 1.

EVPs microRNAs associated with exercise and malignancie.

microRNA	Exercise findings	Proposed mechanisms of microRNA in cancer
miR-106-5p	Altered by a six-month weight-loss trial, including exercise (43)	* Associated with changes in body composition in patients with cancer (43).
miR-122-5p	Not yet explored	* Associated with BMI in breast cancer patients (43).
miR-124	Upregulated in EVPs from adult women submitted to HIIT (16).	* Reduced proliferation, migration, and invasion of nasopharyngeal carcinoma cells via STAT3, p-STAT3, CCND2, and MMP-2 (17). * CDK4 and CDK6 are miR-124 targets (18). * Impact HER2 signaling in breast cancer patients (52).
miR-142-5p	Reduced levels in rats submitted to daily moderate aerobic exercise (36).	* Increased in serum exosomes from patients with cervical squamous cell carcinoma (37). * miR-142-5p targets SOCS1, which can modulate cytokine signaling and can induce a remodeling of lymphatic vessel (37, 38).
miR-150-5p	Upregulated in EVPs from adult women submitted to HIIT with normal weight and overweight (16)	* May repress IGF2BP2 and ZEB1, which are associated with chemoresistance, tumor recurrence, cell proliferation, invasion, and metastasis (29, 30, 32)
miR-191-5p	Altered by a six-month weight-loss trial, including exercise (43).	* Associated with BMI changes in breast cancer patients (43).
miR-21	Increased after to low-intensity exercise (45) HIIT (16)	* Involved with bone regeneration and promoted bone marrow-derived stem cells osteogenesis via the PTEN/PI3K/A
miR-215-5p	Baseline levels in circulating EVPs from trained elderly men were upregulated compared to sedentary men (14).	* miR-215 mimic was able to inhibit cell proliferation, migration, and invasion in human colon cancer; antitumor mechanisms of miR-215 were at least in part due to reducing the expression of Yin-Yang 1 (15).
miR-27a-3p	Not yet explored	* Serum miR-27a-3p was negatively correlated with total fat and total mass (43).
miR-29b	Increased in sedentary elderly individuals immediately after a physical activity session (14).	* Associated with na improvement of bone healing in a fracture model using rodents (46).
miR-320a	Increased in circulating EVPs after aerobic exercise (16)	* Tumor suppressor in glioma by targeting aquaporin 4, a gene highly expressed in gliomas and involved with glioma progression (34). * Inhibits c-Myc, acting on both cellular proliferation and invasion processes (35).
miR-342-5p	Increased after 1-year rowing training and in rats that swam twice daily for 4 weeks (54).	* Upregulation inhibits HER2 and is associated with better overall survival and increased time to recurrence in breast cancer patients (53).
miR-34a/b	Increased in circulating EVPs from trained or sedentary elderly (14).	* Inhibit gastric cancer progression and development. * Have antitumor roles; inhibit cell proliferation and invasion; and suppressed tumor growth in vivo (26). * Acts as a tumor suppressor via downregulating NOX2 expression in human glioma cells (27).
miR-486-5p	* Reduction in trained individuals immediately after a single bout of acute exercise, the sedentary group presented an increase in miR-486-5p levels (14). * Increased levels in exercised mice (23).	* Decreased breast cancer cell proliferation and induced a G1 cell arrest, acting on the oncogene PIM-1. * Inhibited breast cancer xenograft tumor growth in nude mice (25). * Improved the recognition ability of tumor cells by cytotoxic T lymphocytes and natural Killer cells in breast patients, while reduced levels induced in trained individuals briefly after exercising can avoid perpetuation of activation of immune responses (39). * Regulates hematopoietic progenitor growth and erythroid differentiation (41)