Table 2.

Overview of live attenuated PRV vaccine.

Gene-Deleted Vaccines	Vaccine Strains	Deleted Gene(s)	Growth characteristics compared with parents	Target animals	References
Single-gene deletion	TJ	gE	Significantly lower growth kinetics	Piglet	Wang C. H. et al. (2014)
Double-gene deletion	JS-2012	gE/gI	Similar growth kinetics, significantly reduced plaque size	Piglet and pregnant sow	Tong et al. (2016)
	XJ	gI/gE	Similar growth kinetics	Piglet	Yin et al. (2017)
	AH02LA	TK/gE	Significantly lower growth kinetics	Piglet and mice	Wang et al. (2018)
Triple-gene deletion	AH02LA	TK/PK/gE	Similar growth kinetics compared to the PRVΔTK&gE-AH02	Piglet and mice	Xu et al. (2022b)
	NY	gE/gI/TK	Similar growth kinetics	Mice	Zhao et al. (2020)
	XJ5	gI/gE/TK	Unclear	Piglet	Wang J. et al. (2020)
	SMX	gI/gE/TK	Growth kinetics were slow in the first 8 h after inoculation and similar thereafter	Piglet, growing pig and sheep	Hu R. M. et al. (2015)
	GL	US7/US8/UL23	Similar growth kinetics	Dog	Yin et al. (2020)
	QYY2012	gE/TK/US3	Slightly decreased growth kinetics	Mice	Deng et al. (2022)
Quintuple-gene deletion	GL	US7/US8/UL23/US3	Significantly lower growth kinetics	Dog	Yin et al. (2020)
	GDFS	gI/gE/US9/US2	Unclear	Piglet	Sun L. et al. (2022)
Quadruple-gene deletion	HN1201	TK/gE/gI/11 k/28 k	Similar growth kinetics, significantly reduced plaque size	Piglet	Yan et al. (2021)
	GX	TK/gI/gE/US9/US2	Slightly reduced plaque size and slightly decreased growth kinetics	Mice and piglet	Li L. et al. (2022)