TABLE 5.
The First Twenty positively correlated groups of gene set enrichment analysis (GSEA) based on their normalized enrichment score (NES) and p-value in HNSC.
| Description | Set size | Enrichment score | NES | p-value | p.adjust | q values | Rank | Leading_edge |
|---|---|---|---|---|---|---|---|---|
| REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | 37 | 0.850 | 2.541 | 0.002 | 0.048 | 0.042 | 3,547 | tags = 78%, list = 10%, signal = 71% |
| KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION | 46 | 0.816 | 2.532 | 0.002 | 0.048 | 0.042 | 4,098 | tags = 72%, list = 11%, signal = 64% |
| KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | 81 | 0.729 | 2.504 | 0.002 | 0.048 | 0.042 | 2,394 | tags = 42%, list = 7%, signal = 39% |
| WP_ALLOGRAFT_REJECTION | 89 | 0.716 | 2.501 | 0.002 | 0.048 | 0.042 | 4,191 | tags = 58%, list = 11%, signal = 52% |
| REACTOME_PD_1_SIGNALING | 26 | 0.897 | 2.484 | 0.002 | 0.048 | 0.042 | 2,260 | tags = 88%, list = 6%, signal = 83% |
| KEGG_ALLOGRAFT_REJECTION | 35 | 0.836 | 2.479 | 0.002 | 0.048 | 0.042 | 4,000 | tags = 80%, list = 11%, signal = 71% |
| KEGG_GRAFT_VERSUS_HoT_DISEASE | 37 | 0.818 | 2.445 | 0.002 | 0.048 | 0.042 | 2,697 | tags = 73%, list = 7%, signal = 68% |
| REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY | 72 | 0.720 | 2.428 | 0.002 | 0.048 | 0.042 | 2,697 | tags = 46%, list = 7%, signal = 43% |
| KEGG_PRIMARY_IMMUNODEFICIENCY | 35 | 0.817 | 2.421 | 0.002 | 0.048 | 0.042 | 4,939 | tags = 69%, list = 13%, signal = 59% |
| PID_IL12_2PATHWAY | 62 | 0.730 | 2.395 | 0.002 | 0.048 | 0.042 | 3,118 | tags = 50%, list = 9%, signal = 46% |
| KEGG_AUTOIMMUNE_THYROID_DISEASE | 50 | 0.755 | 2.369 | 0.002 | 0.048 | 0.042 | 4,000 | tags = 58%, list = 11%, signal = 52% |
| KEGG_TYPE_I_DIABETES_MELLITUS | 41 | 0.769 | 2.346 | 0.002 | 0.048 | 0.042 | 2,704 | tags = 66%, list = 7%, signal = 61% |
| WP_SELECTIVE_EXPRESSION_OF_CHEMOKINE_RECEPTORS_DURING_TCELL_POLARIZATION | 29 | 0.804 | 2.301 | 0.002 | 0.048 | 0.042 | 3,783 | tags = 62%, list = 10%, signal = 56% |
| PID_IL12_STAT4_PATHWAY | 32 | 0.784 | 2.283 | 0.002 | 0.048 | 0.042 | 4,235 | tags = 59%, list = 12%, signal = 53% |
| BIOCARTA_TH1TH2_PATHWAY | 21 | 0.870 | 2.282 | 0.002 | 0.048 | 0.042 | 3,979 | tags = 81%, list = 11%, signal = 72% |
| KEGG_ASTHMA | 28 | 0.799 | 2.273 | 0.002 | 0.048 | 0.042 | 3,668 | tags = 68%, list = 10%, signal = 61% |
| REACTOME_TCR_SIGNALING | 122 | 0.628 | 2.269 | 0.002 | 0.048 | 0.042 | 2,260 | tags = 27%, list = 6%, signal = 25% |
| REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | 186 | 0.592 | 2.260 | 0.002 | 0.048 | 0.042 | 6,416 | tags = 51%, list = 18%, signal = 42% |
| REACTOME_INTERFERON_GAMMA_SIGNALING | 91 | 0.637 | 2.231 | 0.002 | 0.048 | 0.042 | 6,928 | tags = 56%, list = 19%, signal = 46% |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 84 | 0.626 | 2.160 | 0.002 | 0.048 | 0.042 | 3,614 | tags = 43%, list = 10%, signal = 39% |
Notes: Bold values mean pathways related to immune infiltration.