Fig. 2.

Effects of age on cortical FKBP5/1 expression levels over the lifetime and in major psychiatric illnesses. a Trajectory of FKBP5 gene expression in control subjects over the life span in BA9, from foetal time points to 88 years of age (Cohort 1, loess fit curve). FKBP5 gene expression increased over the life course in healthy subjects and was positively correlated with age between 14 and 96 years of age (calculated with Spearman’s correlations). b FKBP51 protein expression in BA9 was positively correlated with age in Cohort 3 (calculated with Spearman’s correlations). c FKBP5 ageing trajectory was significantly heightened in schizophrenia subjects vs controls in BA9 (Cohort 1, comparison of nonparametric curves achieved using sm.ancova statistics). d–e FKBP51 protein ageing trajectories were not significant in cases vs controls in Cohort 2 (BA9) or Cohort 4 (B24a). The plots show a comparison of nonparametric curves achieved using sm.ancova statistics. Abbreviations: BPD bipolar disorder, CTL control, MDD major depressive disorder, SCZ schizophrenia, cohorts detailed in Table 1