Table 3.
Ultrasound characteristics of AR status in different molecular subtypes
| Characteristics | TNBC (n = 18) | Luminal A (n = 36) | Luminal B (n = 23) | HER2 overexpression (n = 27) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AR + (n = 3) | AR– (n = 15) | p value | AR + (n = 30) | AR– (n = 6) | p value | AR + (n = 20) | AR– (n = 3) | p value | AR + (n = 18) | AR– (n = 9) | p value | |
| Shape | 1.000 | 0.167 | 0.453 | 1.000 | ||||||||
| Regular | 0 (0.0%) | 1 (6.7%) | 0 (0.0%) | 1 (16.7%) | 3 (15.0%) | 1 (33.3%) | 2 (11.1%) | 1 (11.1%) | ||||
| Irregular | 3 (100.0%) | 14 (93.3%) | 30 (100.0%) | 5 (83.3%) | 17 (85.0%) | 2 (66.7%) | 16 (88.9%) | 8 (88.9%) | ||||
| Orientation | 1.000 | 0.677 | 1.000 | 0.695 | ||||||||
| Parallel | 2 (66.7%) | 12 (80.0%) | 18 (60.0%) | 3 (50.0%) | 10 (50.0%) | 2 (66.7%) | 10 (55.6%) | 4 (44.4%) | ||||
| Vertical | 1 (33.3%) | 3 (20.0%) | 12 (40.0%) | 3 (50.0%) | 10 (50.0%) | 1 (33.3%) | 8 (44.4%) | 5 (55.6%) | ||||
| Hyperechoic halo | 1.000 | 1.000 | 0.538 | 1.000 | ||||||||
| Absent | 2 (66.7%) | 12 (80.0%) | 16 (53.3%) | 3 (50.0%) | 13 (65.0%) | 1 (33.3%) | 11 (61.1%) | 6 (66.7%) | ||||
| Present | 1 (33.3%) | 3 (20.0%) | 14 (46.7%) | 3 (50.0%) | 7 (35.0%) | 2 (66.7%) | 7 (38.9%) | 3 (33.3%) | ||||
| Margin | 0.515 | 0.066 | / | 0.333 | ||||||||
| Smooth | 0 (0.0%) | 6 (40.0%) | 1 (3.3%) | 2 (33.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (11.1%) | ||||
| Unsmooth | 3 (100.0%) | 9 (60.0%) | 29 (96.7%) | 4 (66.7%) | 20 (100.0%) | 3 (100.0%) | 18 (100.0%) | 8 (88.9%) | ||||
| Posterior acoustic pattern | 0.167 | 0.643 | 0.253 | 1.000 | ||||||||
| No-shadowing | 2 (66.7%) | 15 (100.0%) | 20 (66.7%) | 5 (83.3%) | 11 (55.0%) | 3 (100.0%) | 13 (72.2%) | 6 (66.7%) | ||||
| Shadowing | 1 (33.3%) | 0 (0.0%) | 10 (33.3%) | 1 (16.7%) | 9 (45.0%) | 0 (0.0%) | 5 (27.8%) | 3 (33.3%) | ||||
| Calcification | 1.000 | 0.109 | 1.000 | 1.000 | ||||||||
| Absent | 1 (33.3%) | 7 (46.7%) | 5 (16.7%) | 3 (50.0%) | 8 (40.0%) | 1 (33.3%) | 4 (22.2%) | 2 (22.2%) | ||||
| Present | 2 (66.7%) | 8 (53.3%) | 25 (83.3%) | 3 (50.0%) | 12 (60.0%) | 2 (66.7%) | 14 (77.8%) | 7 (77.8%) | ||||
| Echo pattern | 0.314 | 0.024* | 1.000 | 0.538 | ||||||||
| Hypoechoic | 1 (33.3%) | 1 (6.7%) | 2 (6.7%) | 3 (50.0%) | 1 (5.0%) | 0 (0.0%) | 2 (11.1%) | 0 (0.0%) | ||||
| Heterogeneous | 2 (66.7%) | 14 (93.3%) | 28 (93.3%) | 3 (50.0%) | 19 (95.0%) | 3 (100.0%) | 16 (88.9%) | 9 (100.0%) | ||||
| Adler grade | 1.000 | 1.000 | 0.229 | 1.000 | ||||||||
| 0–2 | 1 (33.3%) | 6 (40.0%) | 15 (50.0%) | 3 (50.0%) | 10 (50.0%) | 3 (100.0%) | 1 (5.6%) | 0 (0.0%) | ||||
| 3 | 2 (66.7%) | 9 (60.0%) | 15 (50.0%) | 3 (50.0%) | 10 (50.0%) | 0 (0.0%) | 17 (94.4%) | 9 (100.0%) | ||||
| Elasticity score | 1.000 | 0.374 | 0.155 | 1.000 | ||||||||
| 2–3 | 2 (66.7%) | 7 (46.7%) | 12 (40.0%) | 4 (66.7%) | 4 (20.0%) | 2 (66.7%) | 4 (22.2%) | 2 (22.2%) | ||||
| 4–5 | 1 (33.3%) | 8 (53.3%) | 18 (60.0%) | 2 (33.3%) | 16 (80.0%) | 1 (33.3%) | 14 (77.8%) | 7 (77.8%) | ||||
| BI-RADS | 1.000 | 0.643 | 1.000 | 0.683 | ||||||||
| 3-4a | 1 (33.3%) | 3 (20.0%) | 10 (33.3%) | 1 (16.7%) | 5 (25.0%) | 1 (33.3%) | 9 (50.0%) | 3 (33.3%) | ||||
| 4b-5 | 2 (66.7%) | 12 (80.0%) | 20 (66.7%) | 5 (83.3%) | 15 (75.0%) | 2 (66.7%) | 9 (50.0%) | 6 (66.7%) | ||||
TNBC, triple-negative breast cancer; HER2, human epidermal growth factor receptor 2; AR, androgen receptor; BI-RADS, breast imaging reporting and data system; * indicates p < 0.05