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. 2023 Mar 16;14:1455. doi: 10.1038/s41467-023-36921-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Mean EC₅₀ ± SD values for strains containing mutations in PfACS10 selected in the Dd2-Polδ line (A268D, A268V, and F427L) and in 3D7 (M300I), are shown for MMV897615, MMV665924, and MMV019719. Assays were run in triplicate and at least repeated twice. ANOVA with Dunnett post-tests compared mutations in the Dd2-Polδ line, a p < 0.001, b p = 0.005. Two-sided unpaired Student’s t test compared 3D7 and ACS10_{M300I_C}. c p = 0.0003, d p = 0.0000008, e p = 0.0016. Source data are provided as a Source Data file and in Supplementary Data 1.