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. 2023 Mar 3;10:1045030. doi: 10.3389/fvets.2023.1045030

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Copyright © 2023 Zamith Cunha, Zannoni, Salamanca, De Silva, Rinnovati, Gramenzi, Forni and Chiocchetti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photomicrographs of the cryosections of the synovial membrane of a horse metacarpophalangeal joint showing cannabinoid receptor type 2 (CB2) (B) and IBA1 (C) immunoreactivity. The white arrows indicate the DAPI (Blue) labeled nuclei (A) of some round macrophage-like synoviocytes lining the joint cavity which co-expressed IBA1 (Red) and bright CB2 (Green) receptor immunoreactivity. The open arrows indicate two cells expressing CB2 receptor immunoreactivity (likely fibroblast-like synoviocytes) which were IBA1 negative. (D) Merged image (Orange). Scale bar = 50 μm.