Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 3;16:1091096. doi: 10.3389/fnmol.2023.1091096

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Fu, Sun, Zhu, Xia, Wen, Xia, Yu, Xu and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Neuropathic pain developed in SCI mice. (A) The SCI mouse model was generated by punching a hole in left L5 segment of spinal cord under vertebra thoracic segment 13 (T13) using a 26G needle. Injury site is marked with a red circle. (B) Hematoxylin and Eosin (H&E) staining of spinal cord sections showed that the injury track only presented in SCI mice, not in naive nor sham mice. (C) The paw-withdrawal threshold of the ipsilateral side of sham mice pre-surgery and three, five, and eight days post operation (DPO), n = 6. (D) The paw-withdrawal threshold of the ipsilateral side of SCI mice significantly dropped at 3 DPO and further decreased by 8 DPO. Baseline 1.3 ± 0.30 g; Day 3, 0.8 ± 0.35 g; Day 5, 0.7 ± 0.28 g; Day 8, 0.3 ± 0.12 g, n = 7. * p < 0.05, ** p < 0.01, **** p < 0.0001, unpaired t-test or one-way ANOVA. n.s. not significant. Scale bar = 100 μm.