Table 2.
Estimates of the global prevalence of cryptococcal meningitis and associated death
| CrAg positive cases (in thousands)a | CM cases (in thousands) | CM deaths (in thousands) | ||||||
|---|---|---|---|---|---|---|---|---|
| 2014 | 2020 | 2007 | 2014 | 2020 | 2007 | 2014 | 2020 | |
| Global | 278.0 (195.5–341.0)b | 179.0 (133.0–219.0) | 957.9 (371.7–1544) | 223.1 (150.6–282.4) | 152.0 (111.0–185.0) | 624.7 (125.0–1124.9) | 181.1 (119.4–234.3) | 112.0 (79.0–134.0) |
| Sub-Saharan Africa | 204.3 (148.4–237.8) | 97.0 (73.0–120.0) | 720.0 (144.0–1300.0) | 162.5 (113.6–193.9) | 82.0 (61.0–101.0) | 504.0 (100.8–907.2) | 135.9 (93.9–163.9) | 71.0 (52.0–88.0) |
| Asia and the Pacific | 52.3 (32.9–74.1) | 51.0 (42.0–60.0) | 133.6 (26.7–240.5) | 43.2 (25.3–64.7) | 44.0 (35.0–51.0) | 67.2 (13.4–121) | 39.7 (20.6–59.7) | 26.0 (21.0–30.0) |
| Latin America | 7.0 (3.6–11.1) | 14.0 (10.0–17.0) | 54.4 (10.9–97.9) | 5.3 (2.6–8.9) | 12.0 (9.0–14.0) | 29.9 (6.0–53.8) | 2.4 (1.1–4.4) | 7.0 (5.0–9.0) |
| Europec and North America | 8.9 (7.0–11.1) | 15.0 (13.0–17.0) | 34.5 (7.1–64.0) | 7.4 (5.7–9.3) | 12.0 (10.5–1.4) | 15.8 (3.1–28.4) | 2.5 (1.8–3.4) | 7.0 (5.7–8.4) |
| Caribbean | 1.8 (1.3–2.2) | 2.0 (1.7–2.3) | 7.8 (1.6–14.1) | 1.4 (1.0–1.8) | 1.7 (1.4–1.9) | 4.3 (0.9–7.8) | 0.7 (0.5–0.9) | 1.0 (0.8–1.0) |
| Middle East and North Africa | 3.6 (2.6–5.0) | 0.5 (0.1–0.6) | 6.5 (11.3–7.6) | 3.3 (2.4–4.5) | 0.4 (0.1–0.5) | 3.6 (0.7–6.4) | 1.9 (1.3–2.7) | 0.2 (0.1–0.3) |
CrAg Cryptococcal antigen; CM Cryptococcal meningitis
aAntigenemia data was not available for estimation of cases in 2007
bData provided as mean (95% confidence interval)
cThe 2020 data contains cases from Central Asia