Trial Information
Disease	Cancer pain
Stage of disease/treatment	Stage IV
Prior therapy	NSAIDs/acetaminophen
Type of study	Randomized controlled trial
Primary endpoint	The proportion of subjects (morphine compared with oxycodone) requiring high-dose opioids on day 0 with the GG genotype (Table 1).
Secondary endpoints	1. The proportion of subjects (morphine compared with oxycodone) requiring high-dose opioids on day 0 with the Non-GG genotype (Table 1). 2. Hospital anxiety and depression scale (Table 8) 3. Quality of life score (Table 9) 4. The pain catastrophizing scale (Table 7) 4. Adverse events (Tables 4 and 10).
Additional details of endpoints or study design	Table 2 details inclusion and exclusion criteria.
Investigator’s analysis	Correlative endpoints met but not powered to assess activity
Additional analysis	Factors influencing pain numerical rating scale on day 8 (Table 5) Factors influencing high-dose opioid cases for titration response (Table 6)