Primary Assessment Method
Title	The proportion of subjects requiring high-dose opioids on day 0 with the GG genotype.
Number of patients screened	378
Number of patients enrolled	140
Number of patients evaluable for toxicity	139
Number of patients evaluated for efficacy	139
Evaluation method	Other: The definition of high-dose opioids was ≥ 10.0 mg morphine or ≥ 7.5 mg oxycodone.
Secondary assessment method
Title	The proportion of subjects requiring high-dose opioids on day 0 with the non-GG genotype.
Number of patients screened	378
Number of patients enrolled	140
Number of patients evaluable for toxicity	139
Number of patients evaluated for efficacy	139
Evaluation method	The definition of high-dose opioids was ≥10.0 mg morphine or ≥7.5 mg oxycodone.