Figure 1.

Prior treatment and time to progression on bintrafusp alfa treatment.^a Prior treatment and disease response to bintrafusp alfa in patients with non-small cell lung cancer that was primary refractory, ie, no disease control with prior anti-PD-(L)1 therapy (A) or had acquired resistance, ie, initial disease control with prior anti-PD-(L)1 therapy, followed by subsequent progression (B). ^aBoxes left of the vertical dashed line indicate sequence of treatment beyond 12 months prior to first dose of bintrafusp alfa. Abbreviations: PD, progressive disease; PD-L1, programmed cell death 1 ligand 1; PR, partial response.