Table 3.
Participant characteristics corresponding to the MSCP
| MSCP 0 n = 56 | MSCP 1 n = 179 | MSCP 2 n = 38 | MSCP 3 n = 169 | MSCP 4 n = 49 | MSCP 5 n = 116 | MSCP 6 n = 213 | ALL n = 820 | p value | |
|---|---|---|---|---|---|---|---|---|---|
| Age at enrollment | 46.5 (34.5, 56.5) | 42.0 (33.0, 55.0) | 55.5 (48.0, 64.0) | 50.0 (40.0, 59.0) | 58.0 (46.0, 64.0) | 49.5 (43.0, 61.0) | 53.0 (43.0, 62.0) | 50.0 (40.0, 60.0) | < 0.001 |
| Gender (male) | 17 (30) | 84 (47) | 14 (37) | 84 (50) | 26 (53) | 57 (49) | 107 (50) | 389 (47) | 0.1211 |
| Race | 0.7264 | ||||||||
| Black | 2 (4) | 8 (5) | 2 (6) | 10 (6) | 0 (0) | 6 (5) | 12 (6) | 40 (5) | |
| Other | 7 (13) | 27 (15) | 3 (8) | 14 (8) | 8 (16) | 14 (12) | 28 (13) | 101 (12) | |
| White | 45 (83) | 141 (80) | 31 (86) | 144 (86) | 41 (84) | 96 (83) | 172 (81) | 670 (83) | |
| Body mass index (kg/m2) | 24.6 (22.0, 28.1)2 | 27.3 (23.9, 32.2)3 | 25.6 (22.7, 30.3)2 | 27.2 (23.9, 31.0)1 | 26.0 (22.2, 28.3)1 | 25.8 (22.2, 30.1) | 23.2 (20.7, 26.8)1 | 25.7 (22.3, 29.7)10 | < 0.001 |
| Tobacco use (Cigarette smoking, cigar, tobacco chewing) | < 0.001 | ||||||||
| Never | 35 (64)1 | 93 (56)12 | 19 (53)2 | 85 (51)2 | 20 (43)3 | 40 (35)2 | 54 (25)1 | 346 (43)23 | |
| Past | 13 (24) | 51 (31) | 7 (19) | 48 (29) | 15 (33) | 41 (36) | 66 (31) | 241 (30) | |
| Current | 7 (13) | 23 (14) | 10 (28) | 34 (20) | 11 (24) | 33 (29) | 92 (43) | 210 (26) | |
| Cigarette smoking (pack-years) | 7.4 (1.5, 15.4)1 | 8.0 (2.1, 20.0)17 | 37.0 (24.0, 42.5)2 | 19.0 (8.0, 39.8)5 | 19.0 (8.0, 39.8)4 | 14.0 (8.0, 29.0)7 | 19.5 (7.8, 34.5)7 | 15.5 (5.5, 30.0)43 | < 0.001 |
| Drinking status | 0.942 | ||||||||
| Never | 10 (18)1 | 27 (16)12 | 3 (8)2 | 24 (14)2 | 7 (15)3 | 13 (11)2 | 29 (14)1 | 113 (14)23 | |
| Past | 33 (60) | 100 (60) | 25 (69) | 97 (58) | 28 (61) | 77 (68) | 130 (61) | 490 (61) | |
| Current | 12 (22) | 40 (24) | 8 (22) | 46 (28) | 11 (24) | 24 (21) | 53 (25) | 194 (24) | |
| Drinking category | 0.0242 | ||||||||
| Abstainers | 10 (20)6 | 27 (18)27 | 3 (9)6 | 24 (16)22 | 7 (16)4 | 13 (13)12 | 29 (15)21 | 113 (16)98 | |
| Light drinkers | 17 (34) | 40 (26) | 11 (34) | 30 (20) | 6 (13) | 14 (13) | 35 (18) | 153 (21) | |
| Moderate drinkers | 8 (16) | 31 (20) | 8 (25) | 29 (20) | 10 (22) | 25 (24) | 31 (16) | 142 (20) | |
| Heavy drinkers | 9 (18) | 33 (22) | 5 (16) | 32 (22) | 11 (24) | 31 (30) | 36 (19) | 157 (22) | |
| Very heavy drinkers | 6 (12) | 21 (14) | 5 (16) | 32 (22) | 11 (24) | 21 (20) | 61 (32) | 157 (22) | |
| Etiology | < 0.001 | ||||||||
| Alcohol | NA | 28 (16) | NA | 30 (18)4 | 14 (29) | 36 (31) | 97 (46) | 205 (28)4 | |
| All others combined | 41 (23) | 51 (31) | 11 (22) | 34 (29) | 43 (20) | 180 (25) | |||
| Idiopathic | 110 (61) | 84 (51) | 24 (49) | 46 (40) | 73 (34) | 337 (47) | |||
| Diabetes present | 3 (6)5 | 36 (21)8 | 9 (35)12 | 34 (22)14 | 15 (33)3 | 32 (29)4 | 88 (43)8 | 217 (28)54 | < 0.001 |
| Exocrine pancreatic dysfunction | < 0.001 | ||||||||
| No | 36 (84)13 | 92 (51) | 11 (29) | 76 (45) | 19 (39) | 43 (37) | 38 (18) | 315 (39) | |
| Not tested | 1 (2) | 73 (41) | 23 (61) | 66 (39) | 17 (35) | 41 (35) | 79 (37) | 300 (37) | |
| Yes | 6 (14) | 14 (8) | 4 (11) | 27 (16) | 13 (27) | 32 (28) | 96 (45) | 192 (24) | |
| Calcification present | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 49 (100) | 0 (0) | 213 (100) | 262 (32) | NA |
| Days from enrollment to MRI/MRCPa | − 15.5 (− 88.0, 18.5) | − 7.0 (− 112.0, 10.0) | − 9.5 (− 99.0, 9.0) | − 27.0 (− 163.0, 2.0) | − 115.0 (− 455.0, − 38.0) | − 57.0 (− 185.5, 0.0) | − 109.0 (− 377.0, − 19.0) | 54.0 (− 197.0, 0.0) | < 0.001 |
Medians (25th, 75th quantiles) are reported for continuous variables
Counts (column percentages) are reported for categorical variables
Superscripts indicate the missing value counts and are excluded from the percentage calculation
p values are based on comparing the three groups on each characteristic
a
Negative (positive) numbers indicate that the image scan was before (after) enrollment