Table 5.
Mean T1 SIR values and differences in each MSCP groups, shown with and without adjustment for covariates using the regression model
| T1 SIR | MSCP | Mean (Q1, median, Q3) | Unadjusted mean difference (95% CI) | Adjusted mean difference (95% CI)a |
|---|---|---|---|---|
| T1 score: pancreas-to-spleen | 0 | 1.34 (1.22, 1.35, 1.51) | Reference | Reference |
| 1 | 1.27 (1.08, 1.29, 1.46) | − 0.07 (− 0.17, 0.03) | − 0.04 (− 0.15, 0.06) | |
| 2 | 1.21 (1.04, 1.19, 1.44) | − 0.13 (− 0.27, 0.01) | − 0.08 (− 0.23, 0.07) | |
| 3 | 1.16 (0.96, 1.18, 1.35) | − 0.17 (− 0.28, − 0.07) | − 0.15 (− 0.26, − 0.04) | |
| 4 | 1.18 (0.86, 1.12, 1.49) | − 0.15 (− 0.29, − 0.01) | − 0.08 (− 0.22, 0.06) | |
| 5 | 1.12 (0.86, 1.05, 1.27) | − 0.22 (− 0.33, − 0.10) | − 0.17 (− 0.29, − 0.05) | |
| 6 | 1.05 (0.82, 1.02, 1.25) | − 0.28 (− 0.39, − 0.18) | − 0.23 (− 0.34, − 0.12) | |
| p value | 0.0001 | < 0.0001 | < 0.0001 | |
| T1 score: pancreas-to-muscle | 0 | 1.28 (1.02, 1.33, 1.57) | Reference | Reference |
| 1 | 0.99 (0.62, 0.92, 1.31) | − 0.290 (− 0.43, − 0.15) | − 0.26 (− 0.408, − 0.12) | |
| 2 | 1.17 (0.85, 1.18, 1.54) | − 0.11 (− 0.31, 0.076) | − 0.12 (− 0.320, 0.08) | |
| 3 | 0.96 (0.64, 0.92, 1.32) | − 0.321 (− 0.465, − 0.17) | − 0.30 (− 0.441, − 0.15) | |
| 4 | 1.07 (0.62, 1.08, 1.50) | − 0.21 (− 0.39, − 0.02) | − 0.14 (− 0.334, 0.04) | |
| 5 | 0.98 (0.65, 1.05, 1.20) | − 0.30 (− 0.45, − 0.14) | − 0.25 (− 0.403, − 0.09) | |
| 6 | 0.95 (0.60, 0.97, 1.2) | − 0.33 (− 0.47, − 0.19) | − 0.30 (− 0.444, − 0.15) | |
| p value | 0.0001 | < 0.0001 | 0.0006 | |
| T1 score: pancreas-to-liver | 0 | 1.06 (0.93, 1.05, 1.17) | Reference | Reference |
| 1 | 1.02 (0.84, 1.01, 1.13) | − 0.03 (− 0.11, 0.05) | − 0.04 (− 0.13, 0.05) | |
| 2 | 1.00 (0.85, 0.98, 1.14) | − 0.05 (− 0.17, 0.06) | − 0.02 (− 0.14, 0.10) | |
| 3 | 0.95 (0.78, 0.96, 1.11) | − 0.10 (− 0.19, − 0.02) | − 0.10 (− 0.19, − 0.01) | |
| 4 | 0.95 (0.74, 0.93,1.15) | − 0.11 (− 0.22, 0.00) | − 0.07 (− 0.19, 0.04) | |
| 5 | 0.89 (0.70, 0.82, 1.05) | − 0.16 (− 0.25, − 0.07) | − 0.14 (− 0.24, − 0.04) | |
| 6 | 0.86 (0.67, 0.84, 1.04) | − 0.20 (− 0.28, − 0.11) | − 0.17 (− 0.26, − 0.07) | |
| p value | 0.0001 | < 0.0001 | 0.0004 |
Results are expressed as the unadjusted or adjusted mean difference in T1 score between each CP stage and the reference group (MSCP 0), along with 95% confidence intervals (CI)
The bottom row presents the p value from an overall F-test of any difference among the seven stages of CP
a
Covariates adjusted for are age, gender, race, body mass index, tobacco use, pack-years, drinking status, drinking category, diabetes, and exocrine pancreatic dysfunction