Optimizing the best conditions for the synthesis of tetrazoles in the presence of Co-(PYT)2@BNPs nanocatalyst.
Entry | Amount of the catalyst (mg) | Solvent | NaN3 (mmol) | Time (min) | Temperature (°C) | Yield (%)a |
---|---|---|---|---|---|---|
1 | — | PEG | 1.4 | 150 | 120 | N. R.b |
2 | 40 | PEG | 1.4 | 310 | 120 | 85 |
3 | 50 | PEG | 1.4 | 100 | 120 | 98 |
4 | 50 | PEG | 1.3 | 120 | 120 | 80 |
5 | 50 | DMSO | 1.4 | 100 | 120 | 81 |
6 | 50 | H2O | 1.4 | 100 | Reflux | 20 |
7 | 50 | PEG | 1.4 | 100 | 100 | 49 |
Isolated yield within 120 min.
No reaction.