Fig. 1.

Controlled p25 expression in a p25tg AD mouse model. The transgenic line is initiated by crossing a p25-expressing transgenic mouse with a transgenic mouse expressing the CamKII promoter controlling a transactivator protein regulated by doxycycline intake. P25 mutant mice fed doxycycline do not express P25; in its absence high levels of P25 are expressed in the brain and the mice acquire an AD phenotype; i.e., hyperactive cdk5/p25 activity, Aβ accumulation, hyperphosphorylation of tau, inflammation, and behavioral defects. Cohorts and intraperitoneal injection paradigm: three control groups (left), expressing no p25 are compared to three experimental groups, off doxycycline, expressing p25. One injected with saline, a second injected with TFP5, and a third injected with scrambled peptide at the same dose.