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TFP5 inhibits tau and neurofilament hyperphosphorylation. A) Western blots of brain lysates derived from the standard four cohorts of TFP5-treated and untreated mice showing the expression of pNFH (Smi31 antibody) and hyperphosphorylated tau (pTau 404, AT8 antibodies). B) Quantitation of densities using NIH Image J software scanning protocol. Comparison of lanes 3 and 4 show significant reductions in pNFH and phospho tau expression as a consequence of TFP5 treatment. (n = 5; p < 0.05).
