Table 2. Window between Inhibition of GSK3α Mediated Tau Phosphorylation at Thr213 and β-Catenin Translocation for AZ1080, BRD0705, and Compound 1.
compound | GSK3α p-Thr231 IC50 | β-catenin nuclear translocation EC50 | potency ratio |
---|---|---|---|
AZ1080 | 3.18 μM | 3.27 μM | 1.03× |
BRD0705 | 3.75 μM | >20 μM | >5× |
compound 1 | 0.15 μM | 3.02 μM | 20× |