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. 2023 Feb 22;14(6):1080–1094. doi: 10.1021/acschemneuro.2c00476

Table 2. Window between Inhibition of GSK3α Mediated Tau Phosphorylation at Thr213 and β-Catenin Translocation for AZ1080, BRD0705, and Compound 1.

compound GSK3α p-Thr231 IC50 β-catenin nuclear translocation EC50 potency ratio
AZ1080 3.18 μM 3.27 μM 1.03×
BRD0705 3.75 μM >20 μM >5×
compound 1 0.15 μM 3.02 μM 20×