. 2023 Feb 22;14(6):1080–1094. doi: 10.1021/acschemneuro.2c00476

Table 3. Residence Time of Small Molecules Compound 1, Compound 2, and Compound 3 for GSK3α and GSK3β^a.

K_observed(normalized to DMSO)
compound	GSK3α	GSK3β
compound 1	1	0.91
compound 2	0.54	0.91
compound 3	0.46	0.87

The novel compound 2 and compound 3 demonstrate longer residence times specially at the GSK3α paralog when compared to previously profiled compounds.

Table 3. Residence Time of Small Molecules Compound 1, Compound 2, and Compound 3 for GSK3α and GSK3βa.