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Increased occupancy of Pol II at promoter-proximal regions is associated with both upregulation and downregulation of gene expression. RNA-seq (purple) and Pol II ChIP-seq (pink) coverage maps for RHOB (A), KLF2 (B), RUNX1 (C), SH2B3 (D), TGFB1 (E), and FHL3 (F). Tracks shown are representative of two to three independent experiments.
