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. 2022 Dec 13;43(3):337–349. doi: 10.1177/0272989X221143058

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Decision curve analysis plot for a range of threshold values for natalizumab (19%–40%) and equal constant threshold values for dimethyl fumarate and glatiramer acetate (10%). The x-axis represents the range of threshold values for natalizumab, and the y-axis represents the net benefit for each of the 5 strategies: “treat none,”“treat based on the model,”“treat all with natalizumab,”“treat all with dimethyl fumarate,” and “treat all with glatiramer acetate.” The dashed black line represents the highest net benefit.