Table 2. Parameters for DALYs and Wolbachia programme cost-effectiveness computation.

Parameter	Value	Source
Disability weight for symptomatic cases of DF from WHO, (literature), D	0.211 (0.81)	[42, 43]
Disability weight for symptomatic cases of DHF from WHO, (literature), D	0.5 (0.85)	[43, 44]
Mean disability weight for symptomatic ambulatory, (hospitalized) children cases, D	0.37 (0.52)	[45]
Mean disability weight for symptomatic ambulatory, (hospitalized) adult cases, D	0.42 (0.53)	[45]
Social discount rate for DALYs calculations, r	0.03	[35, 46]
Age-weighting correction constant, C	0.16243	[46]
Parameter of the age-weighting function, β	0.04	[46]
Duration of disability in reported cases	10.4	[27, 47], ARDENT project
Duration of disability in unreported cases	4	[41]
Duration of disability in DHF cases	14	[22, 48]
Discount rate for premature deaths productivity lost	0.03	[35]
Median life expectancy of a Singaporean	85	[49]
Wolbachia steady-state cost per year1 (Mn, SGD)	40	NEA
Wolbachia steady-state cost per year2 (Mn, 2010USD)	22.7	Derived from the NEA estimate
% estimated reduction in dengue from Wolbachia programme3	40%– 80%	[50]

¹Yearly annual average cost of a national Wolbachia programme. This figure comprises renovation and equipment cost for mosquito production facilities; operating costs such as facility rental and maintenance, utilities, and consumables for mosquito production; manpower costs for production and release, and cost of community engagement initiatives.

²We derived the 2010USD cost using the mean exchange rate from 2010 to 2020 and the 2010 price level from the estimate in ¹.

³Estimated in sites undergoing Wolbachia suppression programme trials which already have baseline levels of existing vector control measures.