Table 3. Weibull parametric survival model1 factors associated with all cause attrition from ART (death or LTFU) among DMOC patients.
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
HR (95% CI) | p-value | aHR (95% CI) | p-value | |
Gender | ||||
Female | Reference | Reference | ||
Male | 1.47 (1.26–1.72) | <0.001 | 1.64 (1.39–1.92) | <0.001 |
Age group | ||||
18–29 years old | 1.62 (1.34–1.96) | <0.001 | 1.63 (1.35–1.98) | <0.001 |
30–39 years old | Reference | Reference | ||
≥ 40 years old | 0.81 (0.68–0.96) | 0.01 | 0.83 (0.70–0.98) | 0.03 |
CD4 group2, cells/μL | ||||
≥ 200 | Reference | Reference | ||
<200 | 1.25 (0.92–1.70) | 0.16 | 1.03 (0.75–1.42) | 0.83 |
Not done | 0.69 (0.17–2.76) | 0.59 | 0.61 (0.15–2.45) | 0.48 |
VL group2, copies/ml | ||||
<50 | Reference | Reference | ||
50–199 | 1.20 (0.97–1.48) | 0.10 | 1.11 (0.90–1.38) | 0.33 |
200–399 | 1.05 (0.74–1.51) | 0.77 | 1.01 (0.70–1.45) | 0.97 |
Time on ART prior enrollment (1 year increase) | 0.89 (0.86–0.93) | <0.001 | 0.92 (0.89–0.95) | <0.001 |
ART regimen on enrollment | ||||
First Line ART | Reference | Reference | ||
Second line ART | 1.00 (0.71–1.40) | 0.99 | 1.37 (0.96–1.94) | 0.08 |
Model type | ||||
Facility AC | Reference | Reference | ||
Community AC | 1.36 (0.77–2.40) | 0.28 | 1.44 (0.81–2.54) | 0.21 |
CAG | 1.37 (0.88–2.12) | 0.17 | 1.41 (0.91–2.20) | 0.13 |
SFLA | 0.69 (0.55–0.88) | 0.003 | 0.85 (0.65–1.12) | 0.25 |
PuP | 1.10 (0.92–1.30) | 0.29 | 1.25 (1.02–1.55) | 0.03 |
Year of DMOC enrollment3 | 0.95 (0.90–0.99) | 0.02 | 0.94 (0.88–1.00) | 0.04 |
1 Weibull model with adjustment for clustering at health center and an individual levels
2 Last known measure prior DMOC enrollment
3 Year of enrollment into a DMOC model, 2012–2013 as a reference, 1 year increase
Abbreviations: DMOC, differentiated model of HIV care; CAG, community ART group; AC, adherence club; SFLA, spaced and fast lane appointment model; PuP, decentralized medication delivery at community pick up points; SoC, standard of care; ART, antiretroviral therapy; VL, viral load; HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval