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. 2022 Dec 14;2(12):e0000336. doi: 10.1371/journal.pgph.0000336

Table 3. Weibull parametric survival model1 factors associated with all cause attrition from ART (death or LTFU) among DMOC patients.

Univariate analysis Multivariate analysis
HR (95% CI) p-value aHR (95% CI) p-value
Gender
    Female Reference Reference
    Male 1.47 (1.26–1.72) <0.001 1.64 (1.39–1.92) <0.001
Age group
    18–29 years old 1.62 (1.34–1.96) <0.001 1.63 (1.35–1.98) <0.001
    30–39 years old Reference Reference
    ≥ 40 years old 0.81 (0.68–0.96) 0.01 0.83 (0.70–0.98) 0.03
CD4 group2, cells/μL
    ≥ 200 Reference Reference
    <200 1.25 (0.92–1.70) 0.16 1.03 (0.75–1.42) 0.83
    Not done 0.69 (0.17–2.76) 0.59 0.61 (0.15–2.45) 0.48
VL group2, copies/ml
    <50 Reference Reference
    50–199 1.20 (0.97–1.48) 0.10 1.11 (0.90–1.38) 0.33
    200–399 1.05 (0.74–1.51) 0.77 1.01 (0.70–1.45) 0.97
Time on ART prior enrollment (1 year increase) 0.89 (0.86–0.93) <0.001 0.92 (0.89–0.95) <0.001
ART regimen on enrollment
    First Line ART Reference Reference
    Second line ART 1.00 (0.71–1.40) 0.99 1.37 (0.96–1.94) 0.08
Model type
    Facility AC Reference Reference
    Community AC 1.36 (0.77–2.40) 0.28 1.44 (0.81–2.54) 0.21
    CAG 1.37 (0.88–2.12) 0.17 1.41 (0.91–2.20) 0.13
    SFLA 0.69 (0.55–0.88) 0.003 0.85 (0.65–1.12) 0.25
    PuP 1.10 (0.92–1.30) 0.29 1.25 (1.02–1.55) 0.03
Year of DMOC enrollment3 0.95 (0.90–0.99) 0.02 0.94 (0.88–1.00) 0.04

1 Weibull model with adjustment for clustering at health center and an individual levels

2 Last known measure prior DMOC enrollment

3 Year of enrollment into a DMOC model, 2012–2013 as a reference, 1 year increase

Abbreviations: DMOC, differentiated model of HIV care; CAG, community ART group; AC, adherence club; SFLA, spaced and fast lane appointment model; PuP, decentralized medication delivery at community pick up points; SoC, standard of care; ART, antiretroviral therapy; VL, viral load; HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval