Table 1.

Literature collection of mitochondrial DNA alterations in different adverse fertility-related factors

Mitochondrial DNA (mtDNA) alterations	Aging	Assisted reproductive technology (ART)			Diabetes	Obesity
		Controlled ovarian hyperstimulation (COH)	In vitro maturation and culture	Mitochondria replacement technology (MRT)
Quantitative alterations, including the changes of mitochondria number	Human [7, 9, 52–56, 64] Mice [50, 51, 66, 82] Bovine [65]	Human [90] Mice [66, 82] Golden hamsters [81]	Human [8, 84, 90] Mice [91] Rats [83] Equine [89]		Mice [67]	Mice [71, 73]
Qualitative alterations: mtDNA mutations (point mutations, deletions, insertions, duplications and rearrangements) and the expression of mtDNA	Human [12, 56–59, 61, 63] Bovine [60]	Mice [80] Rhesus macaques [79]	Mice [93] Rhesus macaques [86] Bovine [85]	Human [100]

The blank space indicates the absence of related literature