From December 5th 2020 to December 31st 2021 a total of 3610 samples were sequenced with sufficient coverage obtained for 2975 (82·4%) to enable assignment to a Pango lineage. For each of the 17 CARPHA CMS participating in the COVID-19 IMPACT project (i.e., Anguilla, Antigua and Barbuda, Bahamas, Barbados, Bermuda, British Virgin Islands, Cayman Islands, Dominica, Grenada, Guyana, Jamaica, Montserrat, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Turks and Caicos Islands, and T&T) the percentages of VOCs (Alpha, Beta, Gamma, Delta, and Omicron) and VOIs (Epsilon, Iota, Lambda, and Mu) identified are indicated in a pie chart. All other lineages identified are grouped together and indicated as “Other”. The numbers below the pie charts indicate respectively the number of sequences and lineages identified in each country, as at December 31, 2021. CARPHA = Caribbean Public Health Agency. CMS = CARPHA Member States. VOC = Variants of Concern. VOI = Variants of Interest. Map base layer modified from Serafy et al. 2015 [28] (License CC by 4.0; available at https://doi.org/10.1371/journal.pone.0142022.g001).