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. 2023 Mar 17;21:203. doi: 10.1186/s12967-023-04038-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — FCN1 is upregulated in PIBD and associated with immune response. A The expression level of FCN1 in the rectal biopsies from PIBD and non-IBD subjects of the GSE117993 RNA-seq dataset. The y axis represents log2-scaled normalized counts by applying the regularized log (rlog) algorithm in DESeq2. Upregulated FCN1 expression in the colon B and peripheral whole blood (C) from PIBD and non-IBD subjects of the GSE126124 microarray dataset. The y axis represents log2-scaled normalized gene expression by using the robust multichip average (RMA) algorithm. Unpaired t test was employed to calculate P values. D GO enrichment analysis of DEGs between PIBD and non-IBD subjects. The bar plot exhibits significantly enriched GO terms and the pie chart shows the frequency of FCN1 involved in top 100 enriched GO terms. E The bar plot of significantly enriched FCN1-related MeSH terms of DEGs in PIBD compared with non-IBD subjects. F The protein-protein interaction subnetwork of DEGs associated with FCN1 based on STRING database. G The heatmap visualizing the relative expression of FCN1-associated genes in the GSE117993 dataset. H ROC curves and their corresponding AUCs of FCN1, S100A8 and S100A9 (subunits of calprotectin) in the colon validation datasets