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. 2023 Mar 17;21:203. doi: 10.1186/s12967-023-04038-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — FCN1 is enriched in macrophages of PIBD colon mucosa and related to hyper-inflammation. A Diagram depicting the analysis scheme of public single-cell RNA sequencing data (GSE121380). B t-SNE plots of CD68 (macrophage marker), FCN1 and IL1B at the single-cell level. C The bar plot of significantly enriched GSEA Hallmark pathways in FCN1^high macrophages compared with FCN1^low macrophages. D The enrichment plot of TNFα Signaling via NF-κB pathway. E Heatmaps of FCN1 and the top 15 up-regulated genes of TNFα Signaling via NF-κB pathway in FCN1^high compared with FCN1^low macrophages. F The heatmap showing the overall outgoing signaling patterns of major cell types, including B cells, epithelial cells, FCN1^low macrophages, FCN1^high macrophages, fibroblasts, and T cells, as predicted by CellChat. G-J Heatmaps of differential signaling networks between FCN1^low macrophages and FCN1^high macrophages, including MIF signaling, ICAM signaling, CCL signaling, and BAFF signaling