Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 17;21:203. doi: 10.1186/s12967-023-04038-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Validation of the diagnostic efficacy of FCN1 in our patient cohort. A Immunohistochemistry staining showing increased infiltration of FCN1⁺ cells in colon biopsies of IBD compared with non-IBD subjects. B Immunofluorescence staining showing that FCN1⁺ cells (red) colocalize with CD68⁺ cells (green) in the colon biopsies of children with IBD. Yellow indicates double positive cells. C-F Relative mRNA expression levels of FCN1, LINC10558, S100A8, and S100A9 in PBMCs from our validation cohort were measured by qRT-PCR. Data represent mean ± SD. Unpaired t test was employed to calculate P values. *P < 0.05, ****P < 0.0001. G ROC curves and their corresponding AUCs of FCN1, LINC01558, S100A8, and S100A9 based on relative mRNA expression levels in PBMCs from our validation cohort. H Based on PBMCs isolated from whole blood, FCN1 showed superior sensitivity and specificity for discriminating PIBD patients from non-IBD controls in our validation cohort