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. 2023 Mar 17;16:23. doi: 10.1186/s13045-023-01413-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — ITGB4 has prognostic relevance and inversely correlates with the number of tumor-associated CD45⁺ leukocytes in patients. Representative ITGB4 and corresponding GAPDH Western blot bands in ovarian cancer (OvCa) tissue samples. Overall survival of ITGB4^Lo (75%) vs. ITGB4^Hi (25%) R0-resected serous ovarian cancer patients (A). Representative anti-CD45 and anti-ITGB4 immunostaining images from consecutive intraperitoneal (IP) carcinosis and malignant ascites ovarian cancer patient samples and calculation of the association between both parameters (B). Representative anti-ITGB4 and anti-CD45 immunostaining images from primary and metastatic prostate cancer specimens, ITGB4 levels in different types of prostate cancer samples and association between ITGB4 and number of tumor-associated leukocytes in these samples except lymph node metastases (LNM) (C). TURp = palliative transurethral resection