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. 2023 Mar 17;16:23. doi: 10.1186/s13045-023-01413-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — ITGB4 depletion requires E- and P-selectin double knockout for synergistic tumor growth reduction and is accompanied by increased leukocyte infiltration. Mouse survival after s. c. injection of PC-3 control vs. ITGB4 knockdown cells into E-/P-selectin wildtype, single or double knockout mice (endpoint: xenograft tumor size ~ 1.5 cm³) (A). Representative anti-mCD45 immunostaining images of initial tumor nodules on day 4 after s. c. injection of PC-3 or PaCa5061 control or ITGB4 KD cells into E-/P-selectin wildtype or double knockout mice (B)