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. 2023 Mar 17;42:66. doi: 10.1186/s13046-023-02639-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Inhibition of invadopodia activity by miR-1-3p, miR-26a-1-3p and miR-487b-3p signature. Immunofluorescence analysis of U87MG and T98G cells, transfected with the three-miRNA signature or negative control, plated onto gelatin matrix (green) and cultured for 72 h. Representative images show F-actin structures (red), and nuclei (blue, DAPI). Co-localization of areas of degraded gelatin (black) and F-actin structures is shown in merged images (pink dots indicated by arrows) and reported as zoomed pictures. Experiments were done in triplicates by imaging > 10 fields of view and > 5 cells in each sample. Scale bar = 10 μm Histograms indicate the means±SD of normalized degradation area percentage of cells. * = p ≤ 0.05, *** = p ≤ 0.001