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. 2023 Mar 17;42:65. doi: 10.1186/s13046-023-02638-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effect of METTL3 on SCLC chemoresistance in vivo. A Tumour growth in the METTL3 knockdown groups was measured. H69AR cells were stably transduced with shNC or shMETTL3. Cells were subcutaneously injected into nude mice, and chemotherapeutic drugs or vehicles were administered intraperitoneally. ***P < 0.001. B-C Effect of METTL3 on resistance to chemotherapeutic drugs in nude mice and measurement of the tumour weights ***P < 0.001. D Representative IHC staining of METTL3 in subcutaneous xenografts with or without METTL3 knockdown. Scale bars, 50 μm. E Tumour growth in the METTL3 overexpression groups was measured. H69 cells stably overexpressing METTL3 or control cells were subcutaneously injected into nude mice, and chemotherapeutic drugs or vehicles were administered intraperitoneally. ***P < 0.001. F-G Effect of METTL3 on sensitivity to chemotherapeutic drugs in nude mice and measurement of the tumour weights of different groups. ***P < 0.001. H Representative IHC staining of METTL3 in subcutaneous xenografts with or without METTL3 overexpression. Scale bars, 50 μm