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. 2023 Mar 17;42:65. doi: 10.1186/s13046-023-02638-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — DCP2 prevents SCLC chemoresistance by regulating mitophagy. A CCK-8 assays show that knockdown of DCP2 increased the IC50 values of chemotherapeutic drugs for the chemosensitive H69 and H446 cell lines. *P < 0.05; **P < 0.01; ***P < 0.001. B CCK-8 assays show that DCP2 overexpression decreased the IC50 values of chemotherapeutic agents for the chemoresistant H69AR and H446DDP cell lines. *P < 0.05; **P < 0.01. C-D CCK-8 assays showing the effect of simultaneous METTL3 and DCP2 knockdown on the IC50 of chemotherapeutic drugs for H69AR and H446DDP cells. *P < 0.05; **P < 0.01; ***P < 0.001. E Histogram showing the significantly enriched autophagy-related pathways after GO pathway enrichment analysis of MeRIP-seq data. F Mtphagy images show mitophagy fluorescence, and merged images show colocalization between mitochondrial and lysosomal dyes in SCLC cells overexpressing DCP2 following chemotherapeutic drug treatment. Scale bar represents 25 μm. G-H Mtphagy images show mitophagy fluorescence, and merged images show colocalization between mitochondrial and lysosomal dyes in DCP2-knockdown SCLC cells after chemotherapeutic drug treatment. Scale bar represents 25 μm. I-J Mtphagy images show mitophagy fluorescence, and merged images show colocalization between mitochondrial and lysosomal dyes in SCLC cells with simultaneous knockdown of METTL3 and DCP2 following chemotherapeutic drug exposure. Scale bar represents 25 μm