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. 2023 Mar 17;42:65. doi: 10.1186/s13046-023-02638-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — DCP2 regulates mitophagy mediated by the Pink1-Parkin pathway. A-B qRT–PCR analysis of the mRNA expression of mitophagy-related proteins after knockdown of DCP2 in the drug-sensitive cell lines H69 and H446. **P < 0.01; ***P < 0.001; ns, not significant. C qRT–PCR analysis of the mRNA expression of mitophagy-related proteins after overexpression of DCP2 in the drug-resistant cell lines H69AR and H446DDP. **P < 0.01. D-E Western blot analysis of mitophagy-related protein expression after knockdown of DCP2 (D) and overexpression of METTL3 (E) in the drug-sensitive cell lines H69 and H446. F-G Western blot analysis of mitophagy-related protein expression after knockdown of METTL3 (F) and overexpression of DCP2 (G) in the drug-resistant cell lines H69AR and H446DDP. H Western blot analysis of mitophagy-related protein expression after simultaneous METTL3 and DCP2 knockdown in the drug-resistant cell lines H69AR and H446DDP