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. 2023 Mar 17;42:65. doi: 10.1186/s13046-023-02638-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The METTL3 inhibitor STM2457 reverses chemoresistance in SCLC cells in vitro and in vivo. A-B CCK-8 assay shows that STM2457 (6.25 μM) decreased the IC50 values of chemotherapeutic agents for chemoresistant H69AR and H446DDP cells. *P < 0.05; **P < 0.01; ***P < 0.001. C-D Cell apoptosis and arrest were evaluated by flow cytometry in STM2457-treated (6.25 μM) SCLC cells after chemotherapeutic drug treatment. E-F Effect of STM2457 (6.25 μM) on resistance to chemotherapeutic drugs in nude mice with implanted tumours and measurement of tumour weights for different treatment groups. ***P < 0.001. G Mechanism diagram: The m6A methyltransferase METTL3 promotes SCLC chemoresistance by targeting DCP2, which regulates mitophagy and mitochondrial damage via the Pink1-Parkin pathway