Figure 4:

Linear distribution of the identified putative rpoC compensatory mutations throughout the protein sequence (scale: 100 amino acids per space). The upper part of the image lists the mutations found in our analysis, while the lower part shows mutations reported in the scientific literature. Mutations in red are those already reported elsewhere, but not necessarily underwent experimental confirmation of compensatory behavior. Upper mutations marked with an asterisk (*) are those already reported as compensatory by experimental assays