Table 2C.
Univariate analyses of potential prognostic factors for distant metastasis-free survival (DMFS).
| Factors | DMFS at 1 year (%) | DMFS at 2 years (%) | DMFS at 5 years (%) | p - value |
|---|---|---|---|---|
| Age | ||||
| 65 – 74 years | 50 | 39 | 22 | |
| 75 – 84 years | 51 | 28 | 6 | |
| ≥ 85 years | 25 | – | – | 0.30 |
| Gender | ||||
| Female | 50 | 24 | 12 | |
| Male | 50 | 37 | 17 | 0.50 |
| ECOG score | ||||
| 0 - 1 | 54 | 36 | 18 | |
| 2 - 3 | 30 | 21 | – | 0.003 |
| Charlson Comorbidity Index | ||||
| ≤ 5 | 50 | 38 | 23 | |
| > 5 | 48 | 31 | 9 | 0.20 |
| Clinical tumor classification (cT) | ||||
| 1 | 67 | 50 | – | |
| 2 | 47 | 34 | 9 | |
| 3 | 47 | 34 | 17 | |
| 4 | 56 | 34 | 23 | 1.00 |
| Clinical lymph node classification (cN) | ||||
| Nodal negative (N0) | 39 | 30 | 10 | |
| Nodal positive (N+) | 54 | 36 | 19 | 0.1 |
| Tumor stage (AJCC) | ||||
| 1 - 2 | 38 | 25 | 8 | |
| 3 | 52 | 40 | 17 | |
| 4a | 57 | 35 | 27 | 0.30 |
| Localization of the primary tumor | ||||
| 0 - 18 cm distance from the incisors (cervical) | 53 | 41 | 15 | |
| 18 - 24 cm distance from the incisors (upper thoracic third) | 63 | 40 | 27 | |
| 24 - 32 cm distance from the incisors (middle thoracic third) | 49 | 30 | 9 | |
| 32 - 40 cm distance from the incisors (lower thoracic third) | 36 | 30 | 20 | 0.80 |
| Administration of full-dose RT | ||||
| yes | 53 | 36 | 17 | |
| no | 9 | – | – | < 0.001 |
| Cumulative dose of RT (EQD2) | ||||
| ≤ 50 Gy | 46 | 34 | 19 | |
| > 50 Gy | 53 | 34 | 14 | 0.90 |
| Administration of non-modified, full-dose chemotherapy | ||||
| yes | 67 | 51 | 27 | |
| no | 34 | 18 | 7 | < 0.001 |
| Treatment concept | ||||
| Neoadjuvant CRT followed by surgical resection | 61 | 55 | 36 | |
| Definitive RT/CRT | 46 | 27 | 9 | 0.002 |
ECOG, Eastern Cooperative Oncology Group; AJCC, American Joint Committee on Cancer; RT, radiotherapy; EQD2, equivalent dose in 2 Gy fractions; CRT, chemoradiotherapy. Bold values, significant p-values.