Table 2D.
Univariate analyses of potential prognostic factors for locoregional control (LRC).
| Factors | LRC at 1 year (%) | LRC at 2 years (%) | LRC at 5 years (%) | p - value |
|---|---|---|---|---|
| Age | ||||
| 65 – 74 years | 84 | 71 | 63 | |
| 75 – 84 years | 76 | 64 | 40 | |
| ≥ 85 years | – | – | – | 0.03 |
| Gender | ||||
| Female | 84 | 60 | 43 | |
| Male | 78 | 68 | 57 | 0.90 |
| ECOG score | ||||
| 0 - 1 | 82 | 70 | 58 | |
| 2 - 3 | 64 | 51 | – | 0.05 |
| Charlson Comorbidity Index | ||||
| ≤ 5 | 86 | 71 | 64 | |
| > 5 | 75 | 65 | 46 | 0.20 |
| Clinical tumor classification (cT) | ||||
| 1 | 50 | 50 | – | |
| 2 | 79 | 79 | 68 | |
| 3 | 80 | 66 | 51 | |
| 4 | 86 | 66 | 66 | 0.20 |
| Clinical lymph node classification (cN) | ||||
| Nodal negative (N0) | 63 | 50 | 35 | |
| Nodal positive (N+) | 85 | 73 | 61 | 0.009 |
| Tumor stage (AJCC) | ||||
| 1 - 2 | 64 | 58 | 45 | |
| 3 | 87 | 71 | 54 | |
| 4a | 82 | 71 | 71 | 0.20 |
| Localization of the primary tumor | ||||
| 0 - 18 cm distance from the incisors (cervical) | 92 | 81 | 58 | |
| 18 - 24 cm distance from the incisors (upper thoracic third) | 79 | 63 | 47 | |
| 24 - 32 cm distance from the incisors (middle thoracic third) | 84 | 71 | 58 | |
| 32 - 40 cm distance from the incisors (lower thoracic third) | 69 | 62 | 62 | 0.60 |
| Administration of full-dose RT | ||||
| yes | 80 | 69 | 56 | |
| no | 75 | – | – | 0.50 |
| Cumulative dose of RT (EQD2) | ||||
| ≤ 50 Gy | 81 | 69 | 69 | |
| > 50 Gy | 79 | 67 | 46 | 0.20 |
| Administration of non-modified, full-dose chemotherapy | ||||
| yes | 88 | 79 | 67 | |
| no | 73 | 55 | 45 | 0.02 |
| Treatment concept | ||||
| Neoadjuvant CRT followed by surgical resection | 91 | 83 | 77 | |
| Definitive RT/CRT | 75 | 62 | 46 | 0.009 |
ECOG, Eastern Cooperative Oncology Group; AJCC, American Joint Committee on Cancer; RT, radiotherapy; EQD2, equivalent dose in 2 Gy fractions; CRT, chemoradiotherapy. Bold values, significant p-values.