Table 3: Averaged Scored Response (Mean +/− SD) to Likert Scale Questions by Years Passed Since Last Full Time Training.
(value 1=strongly disagree; value 5=strongly agree). One-Way ANOVA statistics with Tukey post-hoc analysis for comparison between the groups showed no significant difference between the responses for each question and years passed since last full time training . Significant difference is defined as a P value < 0.05. Between groups degrees of freedom, F values, and P values are listed. Abbreviations: ES, exome sequencing; CMA, chromosomal microarray analysis.
| Question | Still in training | 0–5 years | 6–10 years | 11–15 years | 16–20 years | 21+ years | Degrees of freedom | F-value | p-value |
|---|---|---|---|---|---|---|---|---|---|
| 1. Everyone should receive ES at birth | 2.5 ± 1.3 | 1.5 ± 0.7 | 2.2 ± 0.8 | 1.9 ± 0.9 | 1.6 ± 0.7 | 2.2 ± 1.3 | 5 | 2.06 | 0.08 |
| 2. prenatal ES should never be used | 1.7 ± 1.1 | 1.4 ± 0.8 | 1.1 ± 0.3 | 1.3 ± 0.5 | 1.5 ± 0.8 | 1.1 ± 0.3 | 5 | 1.53 | 0.19 |
| 3. Invasive prenatal testing should be offered to every pregnant woman | 3.6 ± 1.2 | 3.9 ± 1.3 | 3.7 ± 1.7 | 3.4 ± 1.3 | 3.9 ± 1.0 | 3.8 ± 1.1 | 5 | 0.31 | 0.91 |
| 4. Prospective parents should be able to request prenatal ES without medical indication | 3.2 ± 1.3 | 2.2 ± 1.3 | 3.3 ± 1.4 | 3.1 ± 1.3 | 2.9 ± 1.5 | 2.6 ± 1.6 | 5 | 1.58 | 0.18 |
| 5. prenatal ES should be the first diagnostic genetic test ordered in the context of an abnormal mid-pregnancy ultrasound | 2.5 ± 1.0 | 1.9 ± 1.0 | 2.7 ± 1.7 | 2.3 ± 1.0 | 2.5 ± 1.1 | 2.6 ± 1.6 | 5 | 0.83 | 0.53 |
| 6. prenatal ES should be the genetic test ordered in the context of an abnormal mid-pregnancy ultrasound BUT only after karyotyping + CMA fails to identify an underlying genetic etiology | 3.9 ± 0.9 | 3.6 ± 1.2 | 4.1 ± 0.8 | 4.4 ± 0.8 | 4.1 ± 0.4 | 4.4 ± 0.7 | 5 | 1.55 | 0.18 |
| 7. prenatal ES should be the first diagnostic genetic test ordered in the context of a positive combined first screen for trisomy 21 | 2.8 ± 1.3 | 1.7 ± 1.2 | 2.6 ± 1.4 | 2.0 ± 1.1 | 1.6 ± 1.1 | 2.5 ± 1.6 | 5 | 2.11 | 0.07 |
| 8. prenatal ES should always be used in the context of advanced maternal age (35 years +). | 2.3 ± 1.2 | 1.4 ± 0.5 | 2.6 ± 1.5 | 1.6 ± 1.0 | 1.6 ± 1.2 | 2.1 ± 1.2 | 5 | 2.17 | 0.07 |
| 9. prenatal ES should be offered to every prospective mother, irrespective of risk, in her first trimester | 2.3 ± 1.4 | 1.4 ± 0.5 | 2.1 ± 1.3 | 2.1 ± 1.2 | 2.1 ± 1.0 | 2.3 ± 1.2 | 5 | 1.26 | 0.29 |
| 10. prenatal ES should be offered to every prospective mother, irrespective of risk, in her second trimester | 2.4 ± 1.4 | 1.6 ± 0.9 | 2.0 ± 1.3 | 2.1 ± 1.2 | 2.1 ± 1.0 | 2.3 ± 1.1 | 5 | 0.98 | 0.43 |
| 11. ES should be performed on all stillbirths | 3.0 ± 1.3 | 3.5 ± 1.6 | 3.1 ± 1.3 | 3.7 ± 1.0 | 3.4 ± 1.3 | 3.0 ± 1.7 | 5 | 0.54 | 0.75 |