Table 3.
LMM associations of biomarkers and symptom severity
| Baseline biomarker and behavioral symptom severity | |||||||
| Behavioral symptoms | |||||||
| CAPS-IV | PCL | PHQ9 | |||||
| Estimate | p | Estimate | p | Estimate | p | ||
| Baseline biomarker | Cortisol | − 0.12 | 0.66 | − 0.45 | 0.02 | − 0.18 | 0.06 |
| IL-6 | − 0.23 | 0.71 | − 0.44 | 0.30 | 0.16 | 0.47 | |
| CRP | − 0.12 | 0.84 | 0.08 | 0.86 | 0.14 | 0.52 | |
| Change in mindfulness to change in biomarkers at week 9 | |||||||
| Biomarkers | |||||||
| ΔCortisol | ΔIL-6 | ΔCRP | |||||
| Estimate | p | Estimate | p | Estimate | p | ||
| ΔFFMQ | 0.04 | 0.02 | − 0.01 | 0.47 | 0.00 | 0.92 | |
| Change in mindfulness or biomarkers to change in symptom severity at week 9 | |||||||
| Behavioral symptoms | |||||||
| ΔCAPS-IV | ΔPCL | ΔPHQ9 | |||||
| Estimate | p | Estimate | p | Estimate | p | ||
| ΔFFMQ | − 0.54 | 0.00 | − 0.25 | 0.00 | − 0.15 | 0.00 | |
| Biomarker | ΔCortisol | 0.05 | 0.76 | − 0.04 | 0.66 | 0.03 | 0.45 |
| ΔIL-6 | − 0.88 | 0.04 | − 0.68 | 0.00 | − 0.01 | 0.94 | |
| ΔCRP | − 1.24 | 0.01 | − 0.55 | 0.03 | − 0.21 | 0.06 | |
Bolded values significant for p < 0.05
LMM linear mixed modeling, CAPS-IV Clinician-Administered PTSD Scale for DSM-IV, PCL PTSD Checklist, FFMQ Five Facet Mindfulness Questionnaire, IL-6 interleukin 6, CRP C-reactive protein, Δ change from baseline