Fig. 3.

Kinesin-1 can write and read the tubulin state in the microtubule lattice. (A) Kinesin-1 reads the tubulin state and binds preferentially to microtubules containing tubulins marked by specific PTMs (magenta circles) or tubulins in the GTP-like/expanded state (thick outline). (B) Static kinesin-1 binding writes an expanded state to a GDP-lattice, enabling through-the-lattice allostery (yellow arrows) with other motors. (C) Walking kinesin-1 writes a GTP-tubulin (expanded) state by creating damage sites in the lattice that can be repaired by soluble GTP-tubulin.