Fig. 4.

Kinesin-1 and kinesin-4 motors communicate allosterically through the microtubule lattice. (A) Individual kinesin-4 motors do not accumulate at microtubule ends because their run length is too short (small purple arrow). (B,C) While walking, (B) kinesin-4 and (C) kinesin-1 motors write changes to the microtubule that work allosterically through the lattice (yellow arrows) to influence other kinesin-4 motors. The increase in binding and motility of kinesin-4 (large purple arrow) enables its accumulation at microtubule ends.