Table 1.
Baseline characteristics of included patients
| Characteristic | Inflammatory bowel disease (IBD) | No inflammatory bowel disease | P valuea | Crohn’s Disease (CD) | Ulcerative Colitis (UC) | P valueb |
|---|---|---|---|---|---|---|
| Count | 50 | 959 | 34 | 16 | ||
| Age, years | 50.4 [39.7–56.8] | 50.7 [39.9–58.7] | 0.81 | 50.4 [37.0–56.7] | 51.6 [43.0–59.8] | 0.76 |
| Female | 62% | 62% | 0.97 | 59% | 69% | 0.50 |
| Caucasian race | 90% | 84% | 0.26 | 94% | 81% | 0.31 |
| BMI, Kg/m2 | 32.5 [27.6–39.7] | 40.2 [33.3–47.4] | <.0001 | 32.9 [27.7–37.1] | 30.8 [27.1–42.5] | 0.99 |
| Hypertension | 36% | 59% | 0.001 | 35% | 38% | 0.88 |
| Statin use | 32% | 48% | 0.02 | 29% | 38% | 0.57 |
| Diabetes Mellitus | 30% | 43% | 0.07 | 32% | 25% | 0.75 |
| Insulin use | 30% | 24% | 0.37 | 35% | 19% | 0.33 |
| Metformin use | 26% | 41% | 0.04 | 26% | 25% | 0.99 |
| Albumin, gm/dl | 4.2 [3.5–4.6] | 4.3 [4.0–4.5] | 0.52 | 4.2 [3.5–4.6] | 4.3 [3.7–4.7] | 0.95 |
| Alkaline phosphatase, IU L−1 | 89 [71–123] | 79 [64–95] | 0.004 | 92 [71–123] | 88 [71–118] | 0.72 |
| Alanine transaminase, IU L−1 | 47 [26–77] | 46 [27–82] | 0.82 | 46 [27–81] | 52 [23–75] | 0.76 |
| Aspartate aminotransferase, IU L−1 | 45 [28–56] | 36 [23–60] | 0.07 | 46 [28–68] | 44 [28–49] | 0.26 |
| Total Bilirubin, mg/dl | 0.5 [0.4–0.7] | 0.4 [0.3–0.6] | 0.002 | 0.6 [0.4–0.8] | 0.4 [0.3–0.6] | 0.04 |
| High-density lipoproteins, mg dl−1 | 50 [37–57] | 42 [36–51] | 0.03 | 47 [37–55] | 53 [35–61] | 0.49 |
| Iron, | 81 [49–100] | 76 [59–95] | 0.79 | 88 [58–107] | 70 [40–92] | 0.35 |
| Low-density lipoproteins, mg dl−1 | 94 [65–114] | 104 [83–129] | 0.03 | 81 [62–103] | 104 [85–124] | 0.14 |
| Total cholesterol, mg dl−1 | 176 [145–201] | 180 [157–209] | 0.37 | 167 [140–196] | 179 [168–224] | 0.26 |
| Triglycerides, mg dl−1 | 87 [71–117] | 79 [64–95] | 0.01 | 86 [71–117] | 88 [71–118] | 0.94 |
| Hematocrit, % | 40.6 [36.8–43.6] | 42.2 [39.3–44.6] | 0.009 | 40.4 [36.8–44.0] | 41.6 [37.2–42.8] | 0.98 |
| Hemoglobin, gm dl−1 | 13.5 [11.8–14.8] | 14.0 [12.9–15.0] | 0.02 | 13.6 [11.9–15.0] | 13.5 [11.6–14.3] | 0.51 |
| Mean platelet volume | 10.6 [10.1–11.2] | 10.6 [10.0–11.3] | 0.81 | 10.6 [9.8–11.2] | 10.6 [10.3–11.2] | 0.74 |
| Platelet count, k ul−1 | 254 [194–302] | 245 [203–289] | 0.92 | 238 [159–286] | 287 [202–334] | 0.15 |
| White blood cells count | 7.2 [5.5–8.3] | 7.4 [6.1–9.0] | 0.13 | 7.5 [5.9–9.1] | 6.7 [5.3–7.4] | 0.11 |
P values are obtained from chi-square/Fisher’s exact or Wilcoxon rank-sum tests
a
p values represent comparison between IBD and No IBD
b
p values represent comparison between CD and UC